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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Related Experiment Video

Updated: Jun 10, 2026

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

[Clinical inertia in geriatrics].

A Samalea Suarez1, X Gérard, J Petermans

  • 1Pharmacien Hospitalier, Université de Liege, Service de Pharmacie Clinique, CHU de Liège, Belgique.

Revue Medicale De Liege
|August 6, 2010
PubMed
Summary

Therapeutic inertia, the failure to adjust medications when needed, impacts chronic disease management, especially in the elderly. Integrating pharmacists into healthcare teams enhances pharmacotherapeutic outcomes for geriatric patients.

Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Public Health

Context:

  • Therapeutic inertia, defined as the "lack of initiation or modification of therapy when appropriate," affects common chronic diseases like hypertension, diabetes, and dyslipidemia.
  • This phenomenon is influenced by various factors, including a lack of specific clinical evidence for elderly populations.
  • Fragile elderly patients are particularly susceptible to inappropriate prescribing due to therapeutic inertia.

Purpose:

  • To explore the causes and consequences of therapeutic inertia in geriatric pharmacotherapy.
  • To highlight the challenges in managing chronic diseases in the elderly due to treatment inertia.
  • To advocate for a multidisciplinary approach to improve pharmacotherapeutic management in geriatric patients.

Summary:

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Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease

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Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
06:52

Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit

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Published on: August 22, 2014

  • Therapeutic inertia leads to suboptimal treatment of chronic conditions, particularly in the elderly.
  • Lack of evidence for geriatric-specific treatments contributes to prescribing inertia.
  • Pharmacist integration into healthcare teams can mitigate these issues.

Impact:

  • Improved pharmacotherapeutic management for geriatric patients.
  • Reduced risks associated with inappropriate prescribing in the elderly.
  • Enhanced multidisciplinary collaboration in geriatric care.
  • Potential for better outcomes in chronic disease management for older adults.