Related Experiment Video

Updated: Jun 10, 2026

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus
10:49

Assays for the Specific Growth Rate and Cell-binding Ability of Rotavirus

Published on: January 28, 2019

Rotavirus genotypes among hospitalized children in Egypt, 2000-2002

David O Matson1, Ibrahim A Abdel-Messih, Carey D Schlett

  • 1Center for Pediatric Research, Norfolk, Virginia, USA.

The Journal of Infectious Diseases
|August 6, 2010
PubMed

Insights

Rotavirus surveillance in Egyptian children revealed common strains (G1p[8], G2p[4], G4p[8]) predominated. However, the emergent G9 rotavirus type was also detected, highlighting the need for ongoing vaccine effectiveness monitoring.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Rotavirus vaccines are crucial for preventing severe diarrhea in children.
  • Monitoring rotavirus strains is essential for assessing vaccine effectiveness and identifying emerging types.
  • Previous rotavirus strain data from Egypt was limited.

Purpose of the Study:

  • To genotype rotavirus strains circulating in Egyptian children between 2000 and 2002.
  • To identify common and emerging rotavirus types in the study population.
  • To provide baseline data for future rotavirus vaccine impact studies in Egypt.

Main Methods:

  • Hospital-based surveillance for diarrhea in children was conducted.
  • Rotavirus-positive specimens were collected and genotyped.
  • Frequencies of different rotavirus G and P types were determined.

Main Results:

  • A total of 259 rotavirus-positive specimens were identified (25.2% of all diarrhea cases).
  • Common strains, including G1p[8], G2p[4], and G4p[8], accounted for 82.4% of infections.
  • The emergent G9 rotavirus type was detected in 5.3% of the rotavirus-positive samples.

Conclusions:

  • The study identified the predominant rotavirus strains in Egyptian children during 2000-2002.
  • The detection of the G9 type indicates its emergence in the region.
  • Continued rotavirus surveillance is vital for tracking strain prevalence and informing vaccination strategies.

More Related Videos

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR15:16

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Related Concept Videos

Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Bacterial Gastroenteritis01:18

Bacterial Gastroenteritis

Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid receptor...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Retroviruses02:33

Retroviruses

Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...