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A concise synthesis of beta-sitosterol and other phytosterols
Jiliang Hang1, Patrick Dussault
1Department of Chemistry, University of Nebraska-Lincoln, 809 Hamilton Hall, Lincoln, NE 68588-0304, USA.
None:
A convenient synthesis of sidechain-modified phytosterols is achieved via a temporary masking of the stigmasterol 5,6-alkene as an epoxide. Following performance of the desired modification, the alkene is regenerated through a mild deoxygenation. The approach is applied to the syntheses of beta-sitosterol and campesterol acetate, and suggests a facile route to the (Z)-isomers of Delta(22-23) phytosterols.
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