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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

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Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

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Published on: April 26, 2024

Challenges in screening for depression in multiple sclerosis.

Scott B Patten1, Sandy Berzins, Luanne M Metz

  • 1Department of Community Health Sciences and Hotchkiss Brain Institute, University of Calgary, Canada. patten@ucalgary.ca.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 6, 2010
PubMed
Summary
This summary is machine-generated.

Depression screening in multiple sclerosis (MS) shows minimal impact. Persistent depressive symptoms are common, suggesting resources are better used for long-term clinical management rather than screening.

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Published on: January 11, 2020

Area of Science:

  • Neurology
  • Psychiatry
  • Public Health

Background:

  • Screening for depression is often proposed for multiple sclerosis (MS) patients.
  • Previous research indicated minimal impact of screening, even with prompt, evidence-based care.
  • This study investigates challenges in depression screening within the MS population.

Purpose of the Study:

  • To explore the challenges and patterns of depression screening in multiple sclerosis.
  • To evaluate the effectiveness of screening strategies in detecting clinically significant depressive symptoms over time.

Main Methods:

  • Analysis of prospective data from the Canadian Impact of Multiple Sclerosis (CIMS) database.
  • Utilized annual self-report ratings from the Center for Epidemiologic Studies Depression Rating Scale (CES-D).

Main Results:

  • Approximately 30% of participants screened positive for depression at each annual assessment.
  • CES-D scores demonstrated strong year-to-year correlation (Pearson's r = 0.65–0.73).
  • About 10% of those initially below the depression threshold later exceeded it, with half showing significant score increases.

Conclusions:

  • The longitudinal course of depression in MS is often characterized by persistent symptoms in a significant portion of individuals.
  • Screening interventions may be less effective than anticipated for early detection of fluctuating depression.
  • Reallocating resources from screening to enhanced long-term clinical management could be more beneficial for MS patients.