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Published on: May 3, 2018

Ambulatory pulse pressure as a novel predictor for long-term prognosis in essential hypertensive patients

Y-T Kao1, C-C Huang, H-B Leu

  • 1Division of Cardiology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan, ROC.

Journal of Human Hypertension
|August 6, 2010
PubMed

Insights

Ambulatory pulse pressure (PP) effectively predicts long-term mortality and cardiovascular events in hypertensive patients, outperforming standard office blood pressure measurements for risk stratification.

Area of Science:

  • Cardiology
  • Hypertension Research
  • Preventive Medicine

Background:

  • Prognostic value of ambulatory blood pressure (BP) monitoring varies.
  • Hypertension management requires reliable long-term risk prediction.

Purpose of the Study:

  • Investigate ambulatory BP parameters for predicting mortality and cardiovascular (CV) events.
  • Compare prognostic value of ambulatory BP versus office BP.

Main Methods:

  • 412 hypertensive patients (untreated/treated) underwent ambulatory BP monitoring.
  • Follow-up for 8.5 years, linked to National Death Registry.
  • Adjusted analysis for baseline covariates.

Main Results:

  • Ambulatory systolic BP and pulse pressure (PP) predicted all-cause mortality, non-CV mortality, CV disease, and stroke.
  • Ambulatory PP uniquely predicted CV mortality and coronary heart disease.
  • Ambulatory PP showed superior prediction for all-cause mortality compared to ambulatory systolic BP.
  • Office BP lacked predictive value for any outcome.

Conclusions:

  • Ambulatory pulse pressure is a robust predictor of long-term outcomes in hypertensive individuals.
  • Ambulatory BP parameters offer superior risk stratification compared to office BP.
  • Ambulatory BP monitoring is valuable for risk assessment in both treated and untreated hypertensive patients.

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