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Related Concept Videos

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
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Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
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Related Experiment Video

Updated: Jun 10, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
07:33

Intralymphatic Immunotherapy and Vaccination in Mice

Published on: February 2, 2014

Injection allergen immunotherapy for asthma.

Michael J Abramson1, Robert M Puy, John M Weiner

  • 1Epidemiology & Preventive Medicine, Monash University, School of Public Health & Preventive Medicine, The Alfred, Melbourne, Victoria, Australia, 3004.

The Cochrane Database of Systematic Reviews
|August 6, 2010
PubMed
Summary
This summary is machine-generated.

Allergen specific immunotherapy significantly reduces asthma symptoms and medication use, while improving bronchial hyper-reactivity. However, potential local or systemic adverse effects, including anaphylaxis, must be considered.

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Last Updated: Jun 10, 2026

Intralymphatic Immunotherapy and Vaccination in Mice
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Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Allergy and immunology
  • Respiratory medicine
  • Clinical trials

Background:

  • Allergen specific immunotherapy (ASIT) for asthma remains controversial despite demonstrated clinical benefits.
  • Concerns exist regarding the risk of severe adverse events, such as anaphylaxis.
  • Evolving allergen preparations and delivery methods necessitate updated systematic reviews.

Purpose of the Study:

  • To systematically review the efficacy and safety of allergen specific immunotherapy for asthma.
  • To assess the impact of ASIT on asthma symptoms, medication use, and bronchial hyper-reactivity.

Main Methods:

  • Systematic review of randomized controlled trials (RCTs) identified through comprehensive database searches.
  • Inclusion criteria focused on RCTs of ASIT for asthma reporting clinical outcomes.
  • Independent assessment of study eligibility and quality by multiple authors.

Main Results:

  • Eighty-eight RCTs were included, investigating various allergens including house dust mites, pollen, and animal dander.
  • ASIT demonstrated significant reductions in asthma symptoms and medication requirements.
  • Improvements were observed in allergen-specific bronchial hyper-reactivity, though lung function effects were inconsistent.
  • Adverse events included local reactions in 1 in 16 patients and systemic reactions in 1 in 9 patients.

Conclusions:

  • Allergen specific immunotherapy effectively reduces asthma symptoms and medication needs.
  • ASIT improves bronchial hyper-reactivity, with potential benefits comparable to inhaled corticosteroids.
  • The risk of local and systemic adverse events, including anaphylaxis, requires careful consideration.