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Related Experiment Video

Updated: Jun 10, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion

Published on: May 26, 2022

Hydralazine for essential hypertension.

Michael R Kandler¹, Greg T Mah, Aaron M Tejani

¹Surrey Memorial Hospital Pharmacy, Fraser Health Authority, 13750 96 Avenue, Surrey, BC, Canada, V3V 1Z2.

The Cochrane Database of Systematic Reviews

|August 6, 2010

Summary

No randomized controlled trials (RCTs) were found comparing hydralazine to placebo. Therefore, the effectiveness of hydralazine for hypertension treatment on mortality and morbidity remains uncertain.

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Last Updated: Jun 10, 2026

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The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

The Antihypertensive Effects and Mechanisms of Huotan Jiedu Tongluo Decoction in Rats with H-Type Hypertension

Published on: May 17, 2024

Area of Science:

Cardiovascular Medicine
Pharmacology

Background:

Hypertension significantly increases the risk of stroke, myocardial infarction, and heart failure.
Hydralazine, a direct-acting vasodilator, has been used since the 1950s but is often superseded by newer agents due to tolerability.
Its low cost makes hydralazine a common choice in developing countries.

Purpose of the Study:

To evaluate the efficacy of hydralazine versus placebo in randomized controlled trials (RCTs).
To assess hydralazine's impact on mortality, cardiovascular events, adverse events, and blood pressure in primary hypertension.

Main Methods:

Searched major databases (Cochrane, MEDLINE, IPA, EMBASE) up to June 2009.
Included RCTs of oral hydralazine versus oral placebo for primary hypertension.
Excluded studies on secondary or gestational hypertension.

Main Results:

No RCTs comparing hydralazine to placebo were identified for this review.
Insufficient evidence exists to determine hydralazine's effects on mortality, morbidity, or blood pressure compared to placebo.
Reported adverse effects include reflex tachycardia, hemolytic anemia, vasculitis, glomerulonephritis, and lupus-like syndrome.

Conclusions:

Hydralazine may lower blood pressure, but this is based on non-RCT data.
The clinical outcome effects of hydralazine remain uncertain due to a lack of high-quality RCT evidence.