[Evaluation of chosen salivary periodontal disease markers]

There are articles showing promise on diagnostic use of pro-inflammatory markers in certain body fluids. Research on pathogenesis of periodontal diseases concerns evaluation of biochemical and immunological factors in context of their influence on severity, progress and prognosis of the disease. The methods comprised of saliva, gingival sulcus fluid and traditionally serum.

Contemporary view on possibilities of evaluation of some salivary factors in aspect of making periodontal diagnosis and monitoring of this disease was presented, on the basis of chosen literature. Authors evaluated factors such as: host proteins, phenotypic markers, host cells, hormones, bacteria and bacterial products, ions and volatile compounds. Factors in neutrophils, free radicals and significance of oxidative stress, platelet-activating factor (PAF), vascular endothelial growth factor (VEGF), neopterin and immunoglobulins activity, also their role in periodontal pathogenesis, were described. It was concluded, that longer-term, well controlled clinical studies in bigger population should be performed, to confirm significance of specific saliva markers for diagnosis and monitoring of periodontitis and other lesions in oral cavity.