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Antibodies to gut protozoa in commercial immunoglobulin preparations

A M Cevallos1, P D Butcher, A S Arvind

  • 1Department of Gastroenterology, St Bartholomew's Hospital, West Smithfield, London, UK.

Transactions of the Royal Society of Tropical Medicine and Hygiene
|January 1, 1991
PubMed

Using parasite agglutination, indirect immunofluorescence, enzyme-linked immunosorbent assay, and immunoblotting, Giardia lamblia specific antibody was detected in 5 commercially available immunoglobulin (IgG) preparations. IgG antibodies to Entamoeba histolytica were either present in very low titre or were absent. Immunoblotting showed that anti-G. lamblia antibodies were detected towards a range of Giardia proteins, 25-200 kDa. These findings raise the possibility that pooled human IgG preparations could be evaluated in the treatment of chronic giardiasis which is refractory to conventional therapy.

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