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Published on: January 27, 2021
Role of small RNAs in host-microbe interactions
Surekha Katiyar-Agarwal1, Hailing Jin
1Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi 110021, India. katiyars@south.du.ac.in
Annual Review of Phytopathology
|August 7, 2010
Summary
Host small RNAs, including microRNAs (miRNAs) and small interfering RNAs (siRNAs), are crucial for plant immunity against pathogens. These molecules and their associated silencing machinery form a key defense layer, with pathogens evolving strategies to suppress them.
Area of Science:
- Plant biology
- Molecular biology
- Genetics
Background:
- Plant immune responses involve complex gene regulation.
- Host endogenous small RNAs play a vital role in reprogramming gene expression during pathogen attack.
Purpose of the Study:
- To review recent findings on pathogen-regulated host small RNAs (miRNAs and siRNAs) in plant-microbe interactions.
- To highlight the roles of small RNA pathway components in plant immunity.
- To discuss pathogen strategies for suppressing host small RNA pathways.
Main Methods:
- Literature review of recent research on plant small RNAs and immunity.
- Discussion of key small RNA biogenesis and function components (DCLs, RDRs, HEN1, AGOs).
- Analysis of pathogen counter-strategies against host RNA silencing.
Main Results:
- Pathogen-regulated host miRNAs and siRNAs are integral to plant defense.
- Components like Dicer-like proteins, RNA-dependent RNA polymerases, and Argonaute proteins are essential for plant immune responses.
- Pathogens have evolved sophisticated mechanisms to interfere with host small RNA pathways.
Conclusions:
- Host small RNAs and the RNA silencing machinery represent a critical regulatory layer in plant-pathogen interactions.
- Understanding these pathways provides insights into plant defense mechanisms and potential targets for disease management.
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