Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then processed and...
Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein.
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial: Advancing antimicrobial strategies: nucleic acid and peptide-based approaches.

Frontiers in microbiology·2026
Same author

An intracellular release peptide display technology unveils an antimicrobial peptide with low probability for resistance development.

iScience·2025
Same author

Targeting synthesis of the Chromosome Replication Initiator Protein DnaA by antisense PNA-peptide conjugates in <i>Escherichia coli</i>.

Frontiers in antibiotics·2025
Same author

Obstetric Life Support Education for Maternal Cardiac Arrest: A Randomized Clinical Trial.

JAMA network open·2024
Same author

Adaptation of the World Health Organization (WHO) Safe Surgery Checklist for Use With Cesarean Sections: Implementation and Outcomes With the Safe Cesarean Section Checklist.

Cureus·2024
Same author

Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids.

Journal of medicinal chemistry·2024

Related Experiment Video

Updated: Jun 10, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Gene targeting and expression modulation by peptide nucleic acids (PNA).

Peter E Nielsen1

  • 1Department of Cellular and Molecular Medicine, Faculty of Health Sciences, The Panum Institute, University of Copenhagen, Blegdamsvej 3c, DK-2200, Copenhagen N, Denmark. ptrn@sund.ku.dk

Current Pharmaceutical Design
|August 7, 2010
PubMed
Summary

Peptide nucleic acids (PNA) are synthetic DNA/RNA mimics for gene targeting. Research highlights PNA applications in gene regulation, repair, and anti-infectives, showing promise for drug discovery.

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
08:48

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
09:04

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants
08:48

Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

Published on: December 16, 2016

Area of Science:

  • Biochemistry and Molecular Biology
  • Medicinal Chemistry
  • Genetics and Genomics

Background:

  • Peptide nucleic acids (PNA) are synthetic analogs of DNA and RNA.
  • PNAs exhibit sequence-specific binding to nucleic acids.
  • Their structural mimicry offers potential for gene-targeting applications.

Purpose of the Study:

  • To provide an overview of recent advancements in PNA applications.
  • To emphasize PNA's potential in drug discovery and gene-targeting strategies.
  • To discuss PNA's role in RNA interference, DNA targeting, gene repair, and transcription interference.

Main Methods:

  • Review of current scientific literature on PNA.
  • Emphasis on experimental progress in PNA-based gene targeting.
  • Discussion of PNA delivery systems and anti-infective potential.

Main Results:

  • PNAs demonstrate effective sequence-specific hybridization with RNA and DNA.
  • Significant progress has been made in utilizing PNAs for RNA interference (antisense).
  • PNA applications in targeting duplex DNA, gene repair, and transcription interference are advancing.
  • PNA delivery methods and anti-infective properties are under active investigation.

Conclusions:

  • PNAs are versatile molecules with substantial potential in gene targeting.
  • Ongoing research supports PNA's utility in developing novel therapeutic agents.
  • Further development in PNA delivery and application is expected to drive drug discovery.