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Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

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Updated: Jun 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Angiogenesis and chronic kidney disease.

Yohei Maeshima¹, Hirofumi Makino

¹Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. ymaeshim@md.okayama-u.ac.jp.

Fibrogenesis & Tissue Repair

|August 7, 2010

Summary

Chronic kidney disease (CKD) progression involves angiogenesis. Modulating these factors offers potential therapies for CKD and end-stage renal disease (ESRD), requiring further research for optimal treatment strategies.

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Last Updated: Jun 10, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Intravascular Delivery of Biologics to the Rat Kidney

Intravascular Delivery of Biologics to the Rat Kidney

Published on: September 1, 2016

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection

Published on: November 10, 2021

Area of Science:

Nephrology
Cardiovascular Medicine
Angiogenesis Research

Background:

Increasing global prevalence of end-stage renal disease (ESRD) necessitates understanding chronic kidney disease (CKD) progression.
CKD is a significant risk factor for ESRD and complicates cardiovascular disease (CVD).
Emerging research highlights the role of angiogenesis-related factors in CKD development and progression.

Purpose of the Study:

To review the involvement of angiogenesis-related factors in CKD.
To explore the therapeutic potential of modulating these factors for CKD and related conditions.
To identify future research directions for pro- or anti-angiogenic therapies in CKD.

Main Methods:

Literature review of studies on angiogenesis factors in kidney disease.
Analysis of the roles of vascular endothelial growth factor (VEGF)-A and Angiopoietin (Ang)-1 in kidney development and disease.
Examination of therapeutic effects of angiogenesis inhibitors in experimental models.

Main Results:

VEGF-A is crucial for kidney development, glomerular structure, and repair, and implicated in diabetic nephropathy.
Ang-1 promotes blood vessel maturation and shows therapeutic potential in diabetic nephropathy.
Various angiogenesis inhibitors (e.g., angiostatin, endostatin) have demonstrated therapeutic effects in experimental diabetic nephropathy models.

Conclusions:

Angiogenesis-related factors play a significant role in CKD progression.
Targeting these factors presents potential therapeutic avenues for CKD.
Further research is needed to determine optimal therapeutic timing and develop targeted drug delivery systems for CKD patients.