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Listeria monocytogenes Infection of the Brain
Published on: October 2, 2018
[Healthcare associated infection: emerging problem in a neurology department]
Filipe Palavra1, Helena Gens, Carlos Fernandes
1Serviço de Neurologia, Centro Hospitalar de Coimbra - E.P.E., Coimbra.
Insights
Healthcare-associated infections (HAIs) increased in the new Neurology Department despite facility changes. Factors like space restrictions and shared wards may contribute to this rise in infections, necessitating intervention.
Area of Science:
- Infectious Diseases
- Hospital Epidemiology
- Neurology
Context:
- Healthcare-associated infections (HAIs) pose a significant challenge in hospital settings, increasing patient morbidity and healthcare costs.
- The Neurology Department's relocation and changes in facilities prompted a comparative study of HAI prevalence.
- Understanding HAI management difficulties is crucial for improving patient care quality.
Purpose:
- To compare HAI rates between the old and new Neurology Departments.
- To identify microorganisms, antibiotic sensitivities, and patient comorbidities associated with HAIs.
- To assess treatment adequacy and hospitalization duration in relation to HAIs.
Summary:
- A 6-month retrospective review of clinical files for patients with culture-documented HAIs was conducted.
- In the new department, 46 patients had 119 positive cultures, with MRSA, Pseudomonas aeruginosa, and E. coli as prevalent pathogens.
- Ischemic stroke was the primary cause of admission in both departments.
Impact:
- Despite facility upgrades, the new Neurology Department experienced an increase in HAIs.
- Space restrictions and ward sharing with other specialties are identified as potential aggravating factors.
- Aggressive pathogens necessitate rapid, comprehensive interventions to mitigate their impact on clinical practice and hospital stay duration.
Background:
Healthcare-associated infection (HAI) is, nowadays, a serious problem, contributing a lot to the burden of the hospital stays. Its impact is really huge and the study of these matters is taking a growing interest.
Aims:
To compare, in terms of HAI, the current Neurology Department (localized inside the building of Hospital Geral) and the oldest one, which was far away from the institutional campus. To identify difficulties regarding the management of HAI, trying to propose measures for quality improvement.
Methods:
We revised the clinical files of the patients with HAI documented by culture, on a homologue period of 6 months. Variables like more frequently isolated microorganisms, antibiotics sensibilities, patients' comorbidities, treatment adequacy and duration of hospitalization were analyzed.
Results:
In the oldest Department, 23 patients were identified, 8 men (mean +/- 2SD: 80.4 +/- 9.04 years old) and 15 women (77.3 +/- 21.28 years old), with positive microbiological studies (51). Ischemic stroke caused 73.9% of these hospitalizations. Escherichia coli - EC - (27%), methicillin-resistant Staphylococcus aureus - MRSA - (22%) and Klebsiella pneumoniae - KP - (10%) were the most frequently identified microorganisms in the biological samples studied (sputum, urine, blood, urethral exudate and eschar). Amoxicillin/clavulanic acid was the most empirically used antibiotic (only effective on 37% of the cases, according to the sensibility tests). Hospitalizations had an average of 22 days and 1.3 antibiotics per patient were used. At discharge, Rankin had a mode of 5. In the current Department, 46 patients were studied, 22 men (76.4 +/- 22.6 years old) and 24 women (74.1 +/- 32.6 years old), having 119 positive cultures. Again, ischemic stroke caused the majority of the admissions (52.2%). MRSA (26%), Pseudomonas aeruginosa - PA - (17%) and EC (17%) were the most prevalent pathogens (the same biological products were studied, plus lingual exudates and central venous catheter tips). Ciprofloxacin was the most used antibiotic (suitable on 75% of the cases). Internments had an average of 24.3 days and, this time, 2.5 antibiotics were used per patient, by mean. At discharge, Rankin evaluation had again a mode of 5.
Discussion:
Despite the taken measures and change in facilities, HAI had really increased in the Neurology Department. Since human resources are the same, we think are important, as possible aggravating conditions, space restriction and ward sharing with patients of other medical specialities, as it happens in the current Department.
Conclusions:
More aggressive pathogens require a rapid and comprehensive intervention, in order to minimize its impact on daily clinical practice and in the management of hospital stays.
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