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Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...

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Updated: Jun 10, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

[Ulcerative colitis initial presentation with multiple extra-intestinal manifestations].

M Raquel Marques1, Susana Oliveira, J P Gorjão Clara

  • 1Serviço de Medicina IV, Hospital Pulido Valente, Lisboa.

Acta Medica Portuguesa
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Inflammatory bowel disease can manifest with diverse extraintestinal conditions. This case highlights ulcerative colitis presenting initially with systemic symptoms, including arthritis and kidney disease, emphasizing its complex nature.

Related Experiment Videos

Last Updated: Jun 10, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Area of Science:

  • Gastroenterology
  • Rheumatology
  • Nephrology
  • Cardiology

Background:

  • Inflammatory bowel disease (IBD), particularly ulcerative colitis (UC), is associated with various extraintestinal manifestations (EIMs).
  • EIMs can significantly impact patient morbidity and quality of life.
  • Early recognition of EIMs is crucial for comprehensive patient management.

Observation:

  • A 39-year-old female presented with cervicalgia, functional incapacity, asthenia, bilateral arthritis, and bloody diarrhea.
  • Initial investigations revealed anemia, elevated inflammatory markers, impaired renal function (creatinine clearance 42 mL/min, proteinuria 1.2 g/24h), and active ulcerative rectosigmoiditis.
  • Further evaluation indicated ankylosing spondylitis (positive HLA B27), primary sclerosing cholangitis (via MRCP/ERCP), and cardiac involvement (pericardial thickening).

Findings:

  • The patient's gastrointestinal symptoms improved with 5-ASA enemas, sulfasalazine, corticosteroids, and azathioprine.
  • Ankylosing spondylitis achieved remission with adalimumab.
  • The constellation of symptoms pointed towards a systemic inflammatory process initiated by ulcerative colitis.

Implications:

  • This case underscores the systemic nature of ulcerative colitis and the wide spectrum of its extraintestinal involvement.
  • It emphasizes the importance of a multidisciplinary approach in diagnosing and managing complex IBD cases with multiple EIMs.
  • Recognizing EIMs as initial presentations of UC is vital for timely and effective therapeutic interventions.