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Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
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Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
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Related Experiment Video

Updated: Jun 10, 2026

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets
05:49

Procoagulant Platelet Characterization by Measuring Phosphatidylserine Exposure and Microvesicle Release from Human Purified Platelets

Published on: November 29, 2024

Quebec platelet disorder.

Anwar Hussain Abbasi1, Quratulain Shaikh, Syed Ather Hussain

  • 1Department of Medicine, The Aga Khan University Hospital, Karachi. anwar.abbasi@aku.edu

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Quebec platelet disorder is a rare condition causing abnormal platelet function and increased bleeding. This case highlights the diagnostic importance of platelet aggregation testing, especially with epinephrine, in identifying this autosomal dominant disorder.

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Last Updated: Jun 10, 2026

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05:49

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Area of Science:

  • Hematology
  • Genetics
  • Internal Medicine

Background:

  • Quebec platelet disorder (QPD) is a rare autosomal dominant inherited disorder affecting platelet function.
  • It is characterized by a lifelong history of excessive bleeding, often presenting in childhood or after puberty.

Observation:

  • A 33-year-old woman presented with a history of epistaxis, gum bleeding, menorrhagia, and postpartum hemorrhage.
  • Her standard coagulation profile was within normal limits.
  • Platelet function testing revealed abnormal platelet aggregation specifically in response to epinephrine.

Findings:

  • The observed abnormal platelet aggregation pattern with epinephrine is characteristic of Quebec platelet disorder.
  • This finding differentiates QPD from other inherited or acquired bleeding disorders with normal coagulation parameters.

Implications:

  • Accurate diagnosis of Quebec platelet disorder is crucial for appropriate management and genetic counseling.
  • Platelet aggregation assays, particularly with specific agonists like epinephrine, are vital diagnostic tools for identifying rare platelet function disorders.
  • Understanding the specific platelet defect in QPD can inform future therapeutic strategies.