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Updated: Jun 10, 2026

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney

Published on: November 1, 2018

Pauci-immune necrotizing glomerulonephritis.

Abraham Rutgers¹, Jan S F Sanders, Coen A Stegeman

¹Department of Rheumatology en Clinical Immunology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands. a.rutgers@int.umcg.nl

Rheumatic Diseases Clinics of North America

|August 7, 2010

Summary

Pauci-immune necrotizing glomerulonephritis, often linked to ANCA, is a primary cause of rapidly progressive kidney disease. This review covers its pathology, clinical course, and management strategies, including biopsy and ANCA testing.

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Area of Science:

Nephrology
Immunology
Pathology

Background:

Pauci-immune necrotizing glomerulonephritis is the leading cause of rapidly progressive glomerulonephritis.
It is frequently associated with antineutrophil cytoplasmic antibodies (ANCA) and can manifest as part of systemic vasculitis or as a renal-limited disease.

Purpose of the Study:

To review the histopathologic features of pauci-immune glomerulonephritis.
To discuss the pathogenesis of renal-limited disease, clinical course, and treatment strategies.
To evaluate the role of renal biopsy, ANCA testing, and potential interventions like dialysis and transplantation.

Main Methods:

Review of histopathologic changes in renal biopsies.
Analysis of clinical data regarding disease course and treatment outcomes.
Discussion of diagnostic and monitoring tools, including ANCA assays and renal biopsy.

Main Results:

Histopathologic findings in pauci-immune glomerulonephritis are detailed.
Factors influencing disease localization to the kidneys are explored.
Management of relapses and preventive measures are discussed.

Conclusions:

Renal biopsy is crucial for diagnosis and monitoring.
Early and serial ANCA detection aids in disease management.
Treatment strategies encompass immunosuppression, dialysis, and consideration of renal transplantation post-remission.