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Updated: Jun 10, 2026

Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
Published on: June 9, 2016
Unambiguous identification of superparamagnetic iron oxide particles through quantitative susceptibility mapping of
Tian Liu1, Pascal Spincemaille, Ludovic de Rochefort
1Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.
Abstract:
Superparamagnetic iron oxide (SPIO) particles generate signal void regions on gradient echo images due to their strong magnetization. In practice, the signal void region might be indistinguishable from that generated by air. However, the response of SPIO to an externally applied magnetic field is nonlinear. Magnetization of SPIO saturates at around 1 T while magnetization of water and air increase linearly with field strength. Phantom experiment and mice experiments demonstrated the feasibility of a nonambiguous identification of superparamagnetic contrast agents.
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