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Updated: Jun 10, 2026

The Soft Agar Colony Formation Assay
Published on: October 27, 2014
Wnt/beta-catenin signaling in T-cell immunity and cancer immunotherapy
Luca Gattinoni1, Yun Ji, Nicholas P Restifo
1Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
Abstract:
Wnt ligands are lipid-modified secreted glycoproteins that regulate embryonic development, cell fate specification, and the homeostasis of self-renewing adult tissues. In addition to its well-established role in thymocyte development, recent studies have indicated that Wnt/β-catenin signaling is critical for the differentiation, polarization, and survival of mature T lymphocytes. Here, we describe our current understanding of Wnt signaling in the biology of post-thymic T cells, and discuss how harnessing the Wnt/β-catenin pathway might improve the efficacy of vaccines, T-cell-based therapies, and allogeneic stem cell transplantation for the treatment of patients with cancer.
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