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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data

Venkata P Satagopam1, Margarita C Theodoropoulou, Christos K Stampolakis

  • 1Structural and Computational Biology Unit, EMBL, Meyerhofstrasse 1, Heidelberg D69117, Germany.

Database : the Journal of Biological Databases and Curation
|August 7, 2010
PubMed
Summary

Human-gpDB is a new database detailing human G-protein coupled receptors (GPCRs), G-proteins, and effectors. It maps their interactions, aiding research in cell signaling, disease, and drug discovery.

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G Protein-coupled Receptors

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G Protein-coupled Receptors01:15

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G-protein Coupled Receptors01:21

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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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