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Updated: Jun 10, 2026
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Bronchial blood supply after lung transplantation without bronchial artery revascularization
Mark R Nicolls1, Martin R Zamora
1VA Palo Alto/Stanford University School of Medicine, 3801 Miranda Ave., Palo Alto, California 94304, USA. mnicolls@stanford.edu
Purpose Of Review:
This review discusses how the bronchial artery circulation is interrupted following lung transplantation and what may be the long-term complications of compromising systemic blood flow to allograft airways.
Recent Findings:
Preclinical and clinical studies have shown that the loss of airway microcirculations is highly associated with the development of airway hypoxia and an increased susceptibility to chronic rejection.
Summary:
The bronchial artery circulation has been highly conserved through evolution. Current evidence suggests that the failure to routinely perform bronchial artery revascularization at the time of lung transplantation may predispose patients to develop the bronchiolitis obliterans syndrome.
