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Updated: Jun 10, 2026

Induction and Assessment of Exertional Skeletal Muscle Damage in Humans
Published on: December 11, 2016
Effects of flexibility training on eccentric exercise-induced muscle damage
Che-Hsiu Chen1, Kazunori Nosaka, Hsin-Lian Chen
1Department of Physical Education, National Chiayi University, Chiayi County, Taiwan.
Flexibility training, including static stretching (SS) and proprioceptive neuromuscular facilitation (PNF), significantly reduces muscle damage from eccentric exercise. Flexible muscles demonstrate greater resilience to exercise-induced muscle damage.
Area of Science:
- Exercise Physiology
- Sports Science
- Muscle Physiology
Background:
- Eccentric exercise is known to induce significant muscle damage.
- Understanding protective mechanisms against exercise-induced muscle damage is crucial for athletes and researchers.
- Flexibility training's role in mitigating this damage requires further investigation.
Purpose of the Study:
- To investigate if flexibility training can attenuate muscle damage caused by maximal eccentric exercise.
- To compare the effects of static stretching (SS) and proprioceptive neuromuscular facilitation (PNF) on muscle damage markers.
Main Methods:
- Thirty untrained men were divided into SS, PNF, or control groups.
- SS and PNF groups underwent 8 weeks of specific stretching protocols.
- All groups performed maximal eccentric knee flexor contractions, with muscle damage markers assessed pre- and post-exercise.
Main Results:
- Both SS and PNF significantly increased range of motion (ROM) and altered knee flexor optimum angle.
- Compared to controls, SS and PNF groups exhibited less strength loss and faster recovery.
- Reduced muscle soreness and lower plasma creatine kinase and myoglobin levels were observed in SS and PNF groups.
Conclusions:
- Static stretching and PNF training are effective in attenuating eccentric exercise-induced muscle damage.
- Increased muscle flexibility appears to confer resistance to exercise-induced muscle damage.
- Flexible muscles are less susceptible to damage from strenuous eccentric contractions.
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