Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 10, 2026

Murine Bioluminescent Hepatic Tumour Model

Murine Bioluminescent Hepatic Tumour Model

Published on: July 17, 2010

Murine bioluminescent hepatic tumour model.

Simon Rajendran¹, Slawomir Salwa, Xuefeng Gao

¹Cork Cancer Research Centre, Mercy University Hospital and Leslie C. Quick Jnr. Laboratory, University College Cork, Ireland.

Journal of Visualized Experiments : Jove

|August 7, 2010

Summary

This study establishes a novel mouse model for liver metastases, enabling real-time monitoring of tumor growth and drug response using bioluminescent imaging. This model aids in evaluating new liver metastasis therapeutics.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrative analysis of gastric tissue transcriptomes and gastric cancer GWAS implicates candidate susceptibility genes.

American journal of human genetics·2026

Same author

An approach for diagnosis of diarrhea in neonatal piglets based on the core gut microbiota and machine learning.

Frontiers in microbiology·2026

Same author

Protein Design Enters the Artificial Intelligence Era: Foundations, Tools, and Emerging Paradigms.

Computational and structural biotechnology journal·2026

Same author

Root Exudates from Coexisting Plant Species Differentially Shape Soil Microbial Communities and Nutrient Dynamics in a Desert Steppe.

Microorganisms·2026

Same author

Vimentin-NF-κB signaling contributing to IbeA-mediated adhesion, invasion, and biofilm formation during <i>Escherichia coli</i> K1 traversal of the blood-brain barrier.

Frontiers in immunology·2026

Same author

Exogenous Epstein-Barr virus nuclear antigen 1 induces ADAR1-driven tumor resistance against immunotherapy.

Signal transduction and targeted therapy·2026

Area of Science:

Oncology
Preclinical Research
Medical Imaging

Background:

Liver metastases represent a significant challenge in cancer treatment.
Developing reliable preclinical models is crucial for understanding metastatic disease and testing therapies.
Bioluminescence imaging offers a non-invasive method for monitoring tumor progression.

Purpose of the Study:

To establish and validate a mouse model for inducing and analyzing liver metastases.
To utilize bioluminescence imaging for quantitative assessment of tumor growth and response to treatment.
To provide a platform for evaluating therapeutic strategies against liver metastasis.

Main Methods:

Surgical manipulation of the spleen to create a localized liver tumor model.

More Related Videos

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Related Experiment Videos

Last Updated: Jun 10, 2026

Murine Bioluminescent Hepatic Tumour Model

Murine Bioluminescent Hepatic Tumour Model

Published on: July 17, 2010

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Generating a Murine Orthotopic Metastatic Breast Cancer Model and Performing Murine Radical Mastectomy

Published on: November 29, 2018

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

Inoculation of Lewis lung carcinoma cells expressing luciferase into the spleen.

Utilizing the IVIS whole body imaging system for bioluminescence imaging.

Monitoring tumor growth and cell death via changes in bioluminescent signal.

Main Results:

Successful establishment of localized liver tumors in mice.
Quantitative monitoring of tumor growth and viable cell numbers using bioluminescence imaging.
Early detection of tumor cell death and necrosis indicated by reduced bioluminescent signals.
Demonstration of the model's utility in assessing therapeutic efficacy.

Conclusions:

The developed mouse model effectively replicates liver metastases for preclinical studies.
Bioluminescence imaging provides precise, quantitative data on tumor burden and drug response.
This model is valuable for investigating metastatic tumor survival mechanisms and evaluating novel therapeutics for liver metastasis.