Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanistic Models: Compartment Models in Individual and Population Analysis01:23

Mechanistic Models: Compartment Models in Individual and Population Analysis

Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least squares (OLS)...
Friedman Two-way Analysis of Variance by Ranks01:21

Friedman Two-way Analysis of Variance by Ranks

Friedman's Two-Way Analysis of Variance by Ranks is a nonparametric test designed to identify differences across multiple test attempts when traditional assumptions of normality and equal variances do not apply. Unlike conventional ANOVA, which requires normally distributed data with equal variances, Friedman's test is ideal for ordinal or non-normally distributed data, making it particularly useful for analyzing dependent samples, such as matched subjects over time or repeated measures from...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Parametric Survival Analysis: Weibull and Exponential Methods01:14

Parametric Survival Analysis: Weibull and Exponential Methods

Parametric survival analysis models survival data by assuming a specific probability distribution for the time until an event occurs. The Weibull and exponential distributions are two of the most commonly used methods in this context, due to their versatility and relatively straightforward application.
Weibull Distribution
The Weibull distribution is a flexible model used in parametric survival analysis. It can handle both increasing and decreasing hazard rates, depending on its shape parameter...
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Nonparametric Density Estimation of a Long-Term Trend from Repeated Semicontinuous Data.

Journal of the American Statistical Association·2026
Same author

Generative AI-assisted Bayesian-frequentist Hybrid Inference in Single-cell RNA Sequencing Analysis for Genes Associated with Alzheimer's Disease.

medRxiv : the preprint server for health sciences·2026
Same author

Application of the Total Nutrient Index as a Precision Nutrition Tool to Address Dietary Recommendations Across the Life Course.

Journal of the Academy of Nutrition and Dietetics·2026
Same author

Macrophages and Tissue Homeostasis: From Physiological Functions to Disease Onset.

Frontiers in bioscience (Landmark edition)·2025
Same author

GPR65 Functions as a Key Factor of Bone Aging and a Novel Therapeutic Target for Osteoporosis.

Aging cell·2025
Same author

Valid and efficient inference for nonparametric variable importance in two-phase studies.

Biometrics·2025
Same journal

Instrumental Variable Estimation of Marginal Structural Mean Models for Time-Varying Treatment.

Journal of the American Statistical Association·2026
Same journal

Semiparametric Joint Modeling for Survival Analysis with Longitudinal Covariates.

Journal of the American Statistical Association·2026
Same journal

Dimension Reduction for Large-Scale Federated Data: Statistical Rate and Asymptotic Inference.

Journal of the American Statistical Association·2026
Same journal

Facilitating Heterogeneous Effect Estimation via Statistically Efficient Categorical Modifiers.

Journal of the American Statistical Association·2026
Same journal

Functional Integrative Bayesian Analysis of High-dimensional Multiplatform Clinicogenomic Data.

Journal of the American Statistical Association·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

Generalized Functional Linear Models with Semiparametric Single-Index Interactions.

Yehua Li1, Naisyin Wang, Raymond J Carroll

  • 1Department of Statistics, University of Georgia, Athens, GA 30602, yehuali@uga.edu.

Journal of the American Statistical Association
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

We developed new functional generalized linear models for scalar responses with functional covariates. Our approach models complex interactions efficiently, revealing a previously unknown interaction in empirical data.

More Related Videos

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

Related Experiment Videos

Last Updated: Jun 10, 2026

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach
04:35

Development of an Individual-Tree Basal Area Increment Model using a Linear Mixed-Effects Approach

Published on: July 3, 2020

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups
14:14

The Innovation Arena: A Method for Comparing Innovative Problem-Solving Across Groups

Published on: May 13, 2022

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits
08:27

Applying an eMASS Customization Program as a Research Tool to Evaluate Consumer Benefits

Published on: September 27, 2019

Area of Science:

  • Statistics
  • Econometrics
  • Biostatistics

Background:

  • Generalized linear models (GLMs) are widely used but often assume scalar predictors.
  • Functional data analysis (FDA) extends GLMs to incorporate functional predictors, offering richer modeling capabilities.
  • Existing functional GLM methods may lack parsimony or struggle with data-driven basis function selection.

Purpose of the Study:

  • Introduce a novel class of functional generalized linear models (FGLMs) for scalar responses with functional covariates.
  • Develop a parsimonious semiparametric modeling strategy using a single-index structure for interactions.
  • Investigate estimation and asymptotic properties under different functional feature scenarios.

Main Methods:

  • Proposed a two-step estimation procedure utilizing local estimating equations.
  • Considered two scenarios: pre-determined basis functions (e.g., Fourier, wavelet) and data-driven basis functions (e.g., functional principal components).
  • Developed theoretical asymptotic properties for parameter estimates.

Main Results:

  • The proposed FGLM effectively models interactions between scalar covariates and functional predictors.
  • Demonstrated that data-driven basis function estimation increases asymptotic variance of parameter estimates.
  • Successfully applied the method to an empirical dataset, uncovering a significant, previously undetected interaction.

Conclusions:

  • The novel FGLM provides a flexible and parsimonious framework for analyzing scalar responses with functional predictors.
  • The findings highlight the trade-off between model flexibility and estimation precision when using data-driven functional features.
  • The methodology offers a powerful tool for discovering complex relationships in functional data across various scientific domains.