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Chronic Post-Ischemia Pain Model for Complex Regional Pain Syndrome Type-I in Rats
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Published on: January 21, 2020

Central pain syndromes.

Gunnar Wasner1

  • 1Department of Neurology, Division of Neurological Pain Research and Therapy, University Clinic of Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany. g.wasner@neurologie.uni-kiel.de

Current Pain and Headache Reports
|August 7, 2010
PubMed
Summary
This summary is machine-generated.

Central pain is a chronic neuropathic condition resulting from central nervous system lesions. Diagnosis involves clinical evaluation and tests, with management primarily relying on medications like antidepressants and anticonvulsants.

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Area of Science:

  • Neurology
  • Pain Medicine
  • Neuroscience

Background:

  • Central pain is a neuropathic disorder arising from central nervous system (CNS) lesions.
  • Common causes include vascular lesions, multiple sclerosis, and spinal cord injury.
  • Pain onset is typically delayed, localized to the lesioned area, and can be spontaneous or evoked.

Purpose of the Study:

  • To summarize the pathophysiology, diagnosis, and management of central pain.
  • To highlight the challenges in treating this condition.

Main Methods:

  • Review of clinical presentation and diagnostic techniques.
  • Discussion of pathophysiological mechanisms.
  • Overview of current pharmacological management strategies.

Main Results:

  • Central pain involves ectopic neural activity and hyperexcitability due to facilitatory and disinhibitory processes.
  • Diagnosis relies on clinical assessment, imaging, electrophysiology, and quantitative sensory testing.
  • Antidepressants, anticonvulsants, and opioids show efficacy in management.

Conclusions:

  • Central pain is a complex condition requiring accurate diagnosis through comprehensive evaluation.
  • Effective pharmacological management remains a significant challenge, though certain drug classes offer therapeutic benefits.