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Updated: Jun 10, 2026

An Assay for Measuring the Effects of Ethanol on the Locomotion Speed of Caenorhabditis elegans
Published on: April 9, 2015
Does the transcription factor AP-2beta have an impact on the genetic and early environmental influence on ethanol
S Oreland1, L Daoura, L Gustafsson-Ericson
1Division of Pharmacology, Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.
Abstract:
Genes involved in alcoholism have consensus sites for the transcription factor activator protein (TFAP) 2beta. In the present study, we investigated TFAP-2beta protein levels in the ethanol-preferring alko, alcohol (AA) and the ethanol-avoiding alko, non-alcohol (ANA) rat lines. Furthermore, basal and ethanol-induced TFAP-2beta levels were examined in Wistar rats exposed to different early postnatal environments that are known to affect later ethanol consumption. Taken together, we found differences in brainstem TFAP-2beta protein between the AA and ANA rats.
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