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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

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Related Experiment Video

Updated: Jun 10, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
06:47

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells

Published on: May 4, 2018

Mesenchymal stem cells and tooth engineering.

Li Peng1, Ling Ye, Xue-dong Zhou

  • 1State Key Laboratory of Oral Disease, Sichuan University, Chengdu, China.

International Journal of Oral Science
|August 10, 2010
PubMed
Summary
This summary is machine-generated.

Tooth tissue engineering offers a promising alternative to traditional tooth replacement methods. This review highlights mesenchymal stem cells (MSCs) as key players in regenerating natural tooth structures.

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Last Updated: Jun 10, 2026

Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Oral Health Research

Background:

  • Tooth loss negatively impacts oral health, with current prosthetic solutions like dentures and implants facing limitations.
  • Traditional tooth replacement methods have potential safety and longevity concerns.
  • Tooth tissue engineering is emerging as a viable alternative for restoring natural tooth function.

Purpose of the Study:

  • To review recent advancements in using mesenchymal stem cells (MSCs) for tooth regeneration.
  • To explore various sources of MSCs applicable to dental tissue engineering.
  • To summarize the potential of stem cell-based therapies for replacing missing teeth.

Main Methods:

  • Literature review of recent studies on MSCs in tooth regeneration.
  • Identification and categorization of different MSC sources for dental applications.
  • Analysis of the differentiation potential and clinical applicability of various MSC types.

Main Results:

  • Mesenchymal stem cells (MSCs) show significant potential for tooth regeneration.
  • Key MSC sources include stem cells from human exfoliated deciduous teeth (SHEDs), dental pulp (DPSCs), apical papilla (SCAPs), dental follicle (DFSCs), periodontal ligament (PDLSCs), and bone marrow (BMSCs).
  • These MSCs can differentiate into various cell types necessary for forming tooth structures.

Conclusions:

  • Stem cell-based tissue engineering, particularly using MSCs, represents a promising frontier in addressing tooth loss.
  • Further research into the specific MSC sources and their application can lead to innovative dental regenerative therapies.
  • MSCs offer a potentially safer and more effective approach to tooth replacement compared to current prosthetics.