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Manganese superoxide dismutase expression as a function of genotype and lung cancer pathology
Robert C G Martin1, Yan Li, Qiahong Liu
1Department of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA. Robert.martin@louisville.edu
Introduction:
The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue.
Methods:
One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression.
Results:
The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%.
Conclusion:
MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.
