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Updated: Jun 10, 2026
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
Large-pore PDS mesh compared to small-pore PG mesh
J Otto1, M Binnebösel, S Pietsch
1Department of Surgery, University Clinic RWTH Aachen, Pauwelsstrasse, Aachen, Germany. jeotto@ukaachen.d
Summary
A new polydioxanone (PDS) mesh offers improved elasticity and fluid drainage compared to polyglycolic acid (PG) meshes for temporary abdominal closure, reducing inflammation and fibrosis.
Area of Science:
- Biomaterials Science
- Surgical Innovation
- Tissue Engineering
Background:
- Absorbable meshes are crucial for temporary abdominal closure after laparostoma.
- Existing polyglycolic acid (PG) meshes exhibit limited elasticity and impede fluid drainage.
- A novel polydioxanone (PDS) mesh with enhanced porosity and degradation profile was developed.
Purpose of the Study:
- To evaluate the tissue response to a new PDS mesh compared to a PG mesh.
- To assess the PDS mesh's suitability as an absorbable abdominal wall replacement.
Main Methods:
- Implantation of PDS and PG meshes in rat abdominal walls for 7, 21, and 90 days.
- Histological analysis including HE staining and immunohistochemistry (TUNEL, Ki67, TNF-R2, MMP-2, YB1, FVIII, gas6, AXL).
- Quantification of granuloma size, cell turnover, apoptosis, neovascularization, and nerve ingrowth.
Main Results:
- PDS mesh demonstrated attenuated inflammatory and fibrotic reactions compared to PG mesh.
- Smaller granuloma size, reduced cell turnover, and less remodeling (apoptosis, MMP-2, TNF-R2) observed with PDS.
- Increased neovascularization and nerve ingrowth were noted in the PDS mesh group.
Conclusions:
- Monofilament PDS meshes can be engineered to minimize inflammatory and fibrotic responses.
- The PDS mesh preserves elasticity and facilitates intra-abdominal fluid drainage.
- This PDS mesh represents a promising alternative for temporary abdominal closure.
