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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jun 10, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Emerging drugs for high-grade osteosarcoma.

Claudia Maria Hattinger¹, Michela Pasello, Stefano Ferrari

¹Rizzoli Orthopaedic Institute, Pharmacogenomics and Pharmacogenetics Research Unit, Laboratory of Experimental Oncology, Via di Barbiano 1/10, 40136 Bologna, Italy.

Expert Opinion on Emerging Drugs

|August 10, 2010

Summary

This summary is machine-generated.

Innovative treatments for high-grade osteosarcoma (OS) are emerging. This review highlights promising therapeutic markers and drugs in clinical trials for improved pediatric and adolescent OS care.

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Last Updated: Jun 10, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Published on: October 14, 2016

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Area of Science:

Oncology
Pediatric Oncology
Bone Cancers

Background:

Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents.
High-grade OS requires innovative treatment strategies.

Purpose of the Study:

To review promising therapeutic markers and drugs for high-grade OS.
To focus on agents evaluated in clinical trials for potential innovative treatments.

Main Methods:

Literature search covering the last 40 years of OS chemotherapy and targeted therapies.
Inclusion of drugs targeting clinically relevant markers in Phase I, II, or III trials.
Emphasis on novel targeted therapies for high-grade OS.

Main Results:

An updated overview of novel therapeutic approaches for high-grade OS.
Identification of agents currently in or planned for clinical studies.
Focus on treatments with potential clinical usefulness.

Conclusions:

New agents for innovative treatment strategies are anticipated within 5-10 years.
These agents may benefit selected subgroups of high-grade OS patients.
Continued research into targeted therapies is crucial for advancing OS treatment.