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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

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Emerging drugs for high-grade osteosarcoma

Claudia Maria Hattinger1, Michela Pasello, Stefano Ferrari

  • 1Rizzoli Orthopaedic Institute, Pharmacogenomics and Pharmacogenetics Research Unit, Laboratory of Experimental Oncology, Via di Barbiano 1/10, 40136 Bologna, Italy.

Expert Opinion on Emerging Drugs
|August 10, 2010
PubMed
Abstract

Insights

Innovative treatments for high-grade osteosarcoma (OS) are emerging. This review highlights promising therapeutic markers and drugs in clinical trials for improved pediatric and adolescent OS care.

Area of Science:

  • Oncology
  • Pediatric Oncology
  • Bone Cancers

Background:

  • Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents.
  • High-grade OS requires innovative treatment strategies.

Purpose of the Study:

  • To review promising therapeutic markers and drugs for high-grade OS.
  • To focus on agents evaluated in clinical trials for potential innovative treatments.

Main Methods:

  • Literature search covering the last 40 years of OS chemotherapy and targeted therapies.
  • Inclusion of drugs targeting clinically relevant markers in Phase I, II, or III trials.
  • Emphasis on novel targeted therapies for high-grade OS.

Main Results:

  • An updated overview of novel therapeutic approaches for high-grade OS.
  • Identification of agents currently in or planned for clinical studies.
  • Focus on treatments with potential clinical usefulness.

Conclusions:

  • New agents for innovative treatment strategies are anticipated within 5-10 years.
  • These agents may benefit selected subgroups of high-grade OS patients.
  • Continued research into targeted therapies is crucial for advancing OS treatment.

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