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Related Experiment Video

Updated: Jun 10, 2026

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Sensitization to contact allergens and bronchial hyper-responsiveness.

Eva Schnabel¹, Yvonne Schoefer, Chih-Mei Chen

¹Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany. Schnabel@helmholtz-muenchen.de

Contact Dermatitis

|August 10, 2010

Summary

Contact sensitization to fragrance mix I is linked to increased bronchial hyper-responsiveness in women. This suggests airway obstruction may be a co-morbidity in women with fragrance contact allergies.

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Area of Science:

Dermatology
Pulmonology
Allergology

Background:

Contact sensitization to allergens like nickel and fragrance mix I is common.
Potential health effects, particularly on lung function, are understudied.

Purpose of the Study:

To investigate associations between contact sensitization to nickel sulfate and fragrance mix I.
To examine relationships with lung function parameters and bronchial hyper-responsiveness (BHR).

Main Methods:

Population-based study of 1052 adults in Augsburg.
Lung function tests (FEV1, FVC) and BHR assessment.
Patch testing, medical examinations, and interviews; logistic regression analysis.

Main Results:

Women showed higher sensitization rates to nickel and fragrance mix I.
No significant impact of nickel or fragrance sensitization on FEV1 or FVC.
Positive fragrance mix I patch tests correlated with higher BHR in women.

Conclusions:

Contact sensitization to fragrance mix I is associated with elevated BHR in women.
Airway obstruction should be considered in women with fragrance contact allergies.