Related Experiment Video
Updated: Jun 10, 2026
08:25
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Sensitization to contact allergens and bronchial hyper-responsiveness.
Eva Schnabel1, Yvonne Schoefer, Chih-Mei Chen
1Helmholtz Zentrum München, German Research Centre for Environmental Health, Institute of Epidemiology, Neuherberg, Germany. Schnabel@helmholtz-muenchen.de
Contact Dermatitis
|August 10, 2010
Summary
Contact sensitization to fragrance mix I is linked to increased bronchial hyper-responsiveness in women. This suggests airway obstruction may be a co-morbidity in women with fragrance contact allergies.
Area of Science:
- Dermatology
- Pulmonology
- Allergology
Background:
- Contact sensitization to allergens like nickel and fragrance mix I is common.
- Potential health effects, particularly on lung function, are understudied.
Purpose of the Study:
- To investigate associations between contact sensitization to nickel sulfate and fragrance mix I.
- To examine relationships with lung function parameters and bronchial hyper-responsiveness (BHR).
Main Methods:
- Population-based study of 1052 adults in Augsburg.
- Lung function tests (FEV1, FVC) and BHR assessment.
- Patch testing, medical examinations, and interviews; logistic regression analysis.
Main Results:
- Women showed higher sensitization rates to nickel and fragrance mix I.
- No significant impact of nickel or fragrance sensitization on FEV1 or FVC.
- Positive fragrance mix I patch tests correlated with higher BHR in women.
Conclusions:
- Contact sensitization to fragrance mix I is associated with elevated BHR in women.
- Airway obstruction should be considered in women with fragrance contact allergies.
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