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Effects of auranofin on endothelium dependent contractions in isolated rat aorta
J Fontaine1, Z Y Fang, G Berkenboom
1Laboratory of Pharmacology, Erasmus Hospital, Belgium.
Agents and Actions. Supplements
|January 1, 1991
Abstract:
Auranofin (10(-6) and 10(-5)M) reduces the acetylcholine induced relaxation in the isolated rat aorta. Contractions induced by phenylephrine and 5-hydroxytryptamine are enhanced by auranofin 10(-6)M only when endothelium is present. At higher concentration (10(-5)M), it antagonizes the agonist-induced contractions either in the presence or absence of endothelium.