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Published on: December 22, 2023
Diagnosis-specific characteristics of ventricular tachycardia in children with structurally normal hearts
Samuel Wang1, Wei Zhu, Robert M Hamilton
1Cardiology Division, The Hospital for Sick Children, Toronto, Ontario, Canada.
Insights
Ventricular tachycardia (VT) in children with normal hearts varies by type. Left ventricular tachycardia (LVT) and catecholamine-sensitive polymorphic VT (CPVT) carry higher risks than accelerated idioventricular rhythm (AIVR) or right ventricular tachycardia (RVT).
Area of Science:
- Pediatric Cardiology
- Electrophysiology
- Cardiovascular Medicine
Background:
- Advancements in diagnostics refine ventricular tachycardia (VT) classification in children with structurally normal hearts.
- Understanding VT subtypes is crucial for accurate prognosis and effective management in pediatric patients.
Purpose of the Study:
- To analyze the clinical features and outcomes of children with VT using current diagnostic standards.
- To stratify risk and guide treatment for pediatric VT based on specific diagnoses.
Main Methods:
- Retrospective review of 77 patients under 18 years diagnosed with VT (1980-2005).
- Exclusion of patients with systemic illness or underlying heart disease.
- Categorization into accelerated idioventricular rhythm (AIVR), right ventricular tachycardia (RVT), left ventricular tachycardia (LVT), and catecholamine-sensitive polymorphic VT (CPVT).
Main Results:
- AIVR patients were youngest with the mildest outcomes; CPVT patients had the most severe outcomes.
- Ablation success rates were 50% for RVT and 80% for LVT.
- Severe cardiac events occurred in 3/23 LVT patients and 2/5 CPVT patients (one death).
Conclusions:
- VT management and prognosis in children with healthy hearts depend heavily on the specific VT diagnosis.
- LVT and CPVT present significantly higher risks of morbidity and mortality compared to AIVR and RVT.
Background:
Improved mechanistic insights and clinical tools provide increasing diagnostic refinement for ventricular tachycardia in young patients with structurally normal hearts, yielding potentially important prognostic and management implications.
Objective:
The purpose of this study was to survey the clinical characteristics and outcomes of otherwise healthy children with ventricular tachycardia (VT) who were classified according to contemporary diagnostic criteria.
Methods:
A single-center retrospective review of patients younger than 18 years of age with VT diagnosed between January 1980 and December 2005 was undertaken. Patients with significant systemic illness or with underlying structural or functional heart disease were excluded.
Results:
A total of 77 patients met inclusion criteria and were grouped as follows: accelerated idioventricular rhythm (AIVR; n = 19), right ventricular tachycardia (RVT; n = 30), left ventricular tachycardia (LVT; n = 23), and catecholamine sensitive polymorphic VT (CPVT; n = 5). AIVR patients were youngest at diagnosis and had the most benign natural history, while the opposite was true of CPVT patients. Ablation was attempted in 2/30 RVT (50% success) and 10/23 LVT (80% success) patients. Severe cardiac events occurred in 3/23 LVT (no deaths) and 2/5 CPVT (one death) patients.
Conclusion:
The natural history and appropriate management of VT in young patients with structurally normal hearts are highly dependent on the specific diagnosis. LVT and CPVT are associated with significantly greater morbidity and mortality than AIVR and RVT.
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