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Updated: Jun 10, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Dose-escalation models for combination phase I trials in oncology

Paul Hamberg1, Mark J Ratain, Emmanuel Lesaffre

  • 1Department of Medical Oncology, Erasmus University Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands. a.hamberg@erasmusmc.nl

European Journal of Cancer (Oxford, England : 1990)
|August 10, 2010
PubMed
Summary

Designing combination drug phase I trials for cancer is complex. This study discusses key issues and control designs to improve early-stage combination cancer drug development.

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