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Related Experiment Videos

Splenic function in persons with sickle cell trait at moderately high altitude.

R Nuss1, A J Feyerabend, J L Lear

  • 1Colorado Sickle Cell Treatment and Research Center, University of Colorado School of Medicine, Denver 80262.

American Journal of Hematology
|June 1, 1991
PubMed
Summary

Individuals with sickle cell trait living at high altitudes do not experience impaired spleen function. This study found no evidence of splenic dysfunction in sickle cell trait carriers residing at 1,609 m for over 10 years.

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Area of Science:

  • Physiology
  • Altitude Medicine
  • Hematology

Background:

  • Sickle cell trait is a common hemoglobinopathy.
  • Chronic exposure to moderate altitude may affect organ function.
  • The spleen's reticuloendothelial system is crucial for pathogen clearance.

Purpose of the Study:

  • To investigate if sickle cell trait (SCT) affects splenic function in individuals residing at moderate high altitudes.
  • To assess the long-term impact of altitude on spleen function in SCT carriers.

Main Methods:

  • Study included 17 healthy men with SCT and 25 controls with normal hemoglobin.
  • Participants resided at altitudes >= 1,609 m for >= 10 years.
  • Splenic function was evaluated using radionuclide liver-spleen scans and red blood cell pit counts.

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Main Results:

  • No significant differences in splenic function were observed between the sickle cell trait group and the control group.
  • Radionuclide scans and red cell pit counts did not indicate splenic dysfunction in SCT carriers.
  • Long-term residence at moderately high altitude did not impair splenic reticuloendothelial function in individuals with sickle cell trait.

Conclusions:

  • Sickle cell trait does not appear to predispose individuals to splenic dysfunction when living at moderately high altitudes.
  • Chronic exposure to moderate altitude (>= 1,609 m) does not pose a risk for splenic dysfunction in persons with sickle cell trait.
  • Further research may explore other potential altitude-related health effects in SCT populations.