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Related Concept Videos

Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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Related Experiment Video

Updated: Jun 10, 2026

Nuclear Transfer into Mouse Oocytes
14:17

Nuclear Transfer into Mouse Oocytes

Published on: November 30, 2006

Nuclear transfer in mouse oocytes and embryos.

Zhiming Han1, Yong Cheng, Cheng-Guang Liang

  • 1The Fels Institute for Cancer Research and Molecular Biology, Department of Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.

Methods in Enzymology
|August 10, 2010
PubMed
Summary

Nuclear transfer techniques are crucial for understanding development and manipulating genomes. These methods, including somatic cell nuclear transfer, offer applications in animal cloning and human infertility treatment.

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Last Updated: Jun 10, 2026

Nuclear Transfer into Mouse Oocytes
14:17

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Published on: November 30, 2006

Transnuclear Mice with Pre-defined T Cell Receptor Specificities Against Toxoplasma gondii Obtained Via SCNT
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Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

Area of Science:

  • Reproductive biology and developmental genetics.

Background:

  • Nuclear transfer is essential for studying genetic and epigenetic regulation in early development.
  • It elucidates the interactions between the oocyte's cytoplasm and the nucleus.

Purpose of the Study:

  • To review various nuclear transfer techniques.
  • To highlight their applications in developmental biology, genome manipulation, and clinical infertility treatment.

Main Methods:

  • Review of nuclear transfer methods: germinal vesicle transfer, spindle transfer, intracytoplasmic sperm injection, pronuclear transfer, and somatic cell nuclear transfer.

Main Results:

  • Nuclear transfer facilitates dissection of developmental control mechanisms.
  • It enables genome manipulation, such as cloning genetically engineered animals.
  • Applications extend to clinical treatments for infertility.

Conclusions:

  • Nuclear transfer techniques are versatile tools in reproductive science.
  • They offer significant potential for both basic research and therapeutic applications.