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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
Stem cells and DNA damage: persist or perish?
Andrew A Lane1, David T Scadden
1Center for Regenerative Medicine, Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA. aalane@partners.org
Abstract:
Stem cells repopulate tissues after injury while also renewing themselves, but this makes them vulnerable to genotoxic damage. Mohrin et al. (2010) and Milyavsky et al. (2010) now show that mouse and human hematopoietic stem cells make opposing decisions about whether to die or to persist in response to DNA damage.
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