Related Experiment Video

Updated: Jun 10, 2026

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
06:38

Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

Published on: June 11, 2017

The RETHINK project: impact of toxicity testing in the minipig as an alternative approach in regulatory toxicity

Michael J Curtis

    Journal of Pharmacological and Toxicological Methods
    |August 10, 2010
    PubMed
    Abstract

    No abstract available in PubMed .

    More Related Videos

    Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
    08:23

    Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

    Published on: May 12, 2018

    Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
    17:28

    Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

    Published on: June 17, 2015

    Related Experiment Videos

    Last Updated: Jun 10, 2026

    Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach
    06:38

    Use of a Piglet Model for the Study of Anesthetic-induced Developmental Neurotoxicity (AIDN): A Translational Neuroscience Approach

    Published on: June 11, 2017

    Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain
    08:23

    Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain

    Published on: May 12, 2018

    Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
    17:28

    Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

    Published on: June 17, 2015

    Related Concept Videos

    Toxicity Testing in Animals01:23

    Toxicity Testing in Animals

    Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...

    Articles linked to this work by shared authors, journal, and citation graph.

    Signal detection and characterisation of a novel drug-drug interaction between methadone and a synthetic cannabinoid receptor agonist.

    British journal of pharmacology·2026

    Advancing safety pharmacology: Emerging technologies, innovative methods, and future directions.

    Journal of pharmacological and toxicological methods·2026

    Diltiazem N-oxide, a novel ischaemia-activated prodrug, prevents ischaemia-induced ventricular fibrillation without off-target adverse effects.

    British journal of pharmacology·2026

    Antiarrhythmic drugs to prevent sudden cardiac death: Is there a way forward?

    Pharmacology & therapeutics·2026

    Be CLEAR to ensure methodological and data transparency.

    Trends in pharmacological sciences·2025

    Safety Pharmacology: Achieving a quarter century milestone as a scientific discipline.

    Journal of pharmacological and toxicological methods·2025

    A contract research organization perspective on secondary pharmacology: current practices, panel selection, and emerging needs for interpretation.

    Journal of pharmacological and toxicological methods·2026

    Integration of safety pharmacology endpoints into toxicology studies - A survey of GLP institutions in China.

    Journal of pharmacological and toxicological methods·2026

    Weight of evidence in safety pharmacology guidance: A case for explicit probabilistic reasoning in the revision of ICH S7A.

    Journal of pharmacological and toxicological methods·2026

    Impact of filter selection on UPLC quantification of terbinafine hydrochloride: Optimization of sample preparation and method validation.

    Journal of pharmacological and toxicological methods·2026

    Development of spectroscopic methods using charge transfer complex for the quantitative estimation of proguanil hydrochloride: Insights from greenness evaluation, BSA binding, molecular docking, antimicrobial studies and Insilico toxicity assessment.

    Journal of pharmacological and toxicological methods·2026

    Ezetimibe pretreatment attenuates early ischemia-reperfusion injury in a rat model of lung transplantation.

    Transplant immunology·2026

    Identification of priority gaseous component in biodiesel exhaust and its potential pulmonary hazards: a data-driven screening and validation strategy.

    Environment international·2026

    Diffusion model with central annotation propagation for segmentation of ellipsoid zone maps on OCT scans of retinitis pigmentosa.

    Biomedical optics express·2026

    Metabolic Reprogramming by Time-Restricted Feeding Confers Resistance to PM2.5-Induced Metabolic Disturbances in Adipose Tissue.

    The Journal of nutritional biochemistry·2026

    Harnessing the Power of Education for a Low-carbon Future in Anaesthesia: A Narrative Review.

    Turkish journal of anaesthesiology and reanimation·2026

    Climate Change is Rewriting the Hydroclimatic Operating Envelope of Mines.

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us