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Updated: Jun 10, 2026
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Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Published on: June 9, 2018
Transcranial sonography in Huntington's disease
Christos Krogias1, Jens Eyding, Thomas Postert
1Department of Neurology, St. Josef-Hospital, Ruhr University Bochum, Germany.
International Review of Neurobiology
|August 10, 2010
Summary
Transcranial sonography (TCS) offers valuable insights into Huntington
Area of Science:
- Neuroimaging and Neurology
- Neurodegenerative Diseases
Background:
- Transcranial sonography (TCS) is a sensitive tool for evaluating extrapyramidal movement disorders.
- While primarily used for Parkinsonian syndromes, TCS can reveal basal ganglia alterations in Huntington's disease (HD).
Purpose of the Study:
- To review the diagnostic value of TCS in Huntington's disease (HD).
- To explore the relationship between TCS findings and clinical/genetic aspects of HD.
Main Methods:
- Review of existing literature on Transcranial Sonography (TCS) in Huntington's disease (HD).
- Correlation of TCS findings with clinical severity, cognitive performance, depressive symptoms, and CAG repeat numbers.
Main Results:
- TCS identified signal alterations in basal ganglia associated with HD's symptom domains.
- Substantia nigra hyperechogenicity correlated with higher disease severity and increased CAG repeats.
- Third ventricle width correlated with poorer cognitive function; mesencephalic raphe echogenicity with depressive symptoms.
Conclusions:
- TCS is a valuable diagnostic tool for Huntington's disease (HD), correlating with clinical and genetic factors.
- TCS findings provide insights into the pathophysiology of HD, complementing other neuroimaging modalities.
