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Related Experiment Video

Updated: Jun 10, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

[Tetragametic chimerism: Case report].

A Loriaux¹, S Boulet, V Delorme

¹CHU de Grenoble, France.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction

|August 10, 2010

Summary

This summary is machine-generated.

This study details a rare spontaneous monochorionic dizygous pregnancy, revealing a hematopoietic chimera in a female twin due to stem cell exchange. This phenomenon highlights early fetal immune tolerance and potential links to assisted reproduction.

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Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Published on: December 22, 2010

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Last Updated: Jun 10, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

Trans-inner Cell Mass Injection of Embryonic Stem Cells Leads to Higher Chimerism Rates

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Published on: May 29, 2018

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras

Published on: December 22, 2010

Area of Science:

Reproductive biology
Human genetics
Developmental biology

Background:

Monochorionic dizygous pregnancies are rare, involving twins sharing a placenta but originating from separate zygotes.
Hematopoietic chimerism occurs when an individual has cell populations from genetically distinct individuals.
Understanding the mechanisms of twin pregnancies and chimerism is crucial for reproductive medicine.

Observation:

The third documented case of spontaneous monochorionic dizygous pregnancy was identified through fetal sex discordance.
Blood group analysis of the female twin confirmed hematopoietic chimera, indicating shared blood cell origins.
The pregnancy involved a single placenta with vascular connections between the fetuses.

Findings:

Monochorionic dizygous twins may form from the fusion of two zygotes at the late morula stage.
Exchange of stem cells between fetuses during early development can lead to chimerism.
The immature fetal immune system facilitates successful engraftment of cells from the co-twin.

Implications:

This case provides insights into the biological mechanisms underlying rare twin pregnancies and chimerism.
The findings suggest that assisted reproductive technologies might increase the incidence of such pregnancies.
Understanding fetal immune tolerance is key to managing potential complications and future reproductive strategies.