Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Reactions02:06

Allergic Reactions

Overview
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The immune profile of human seminal plasma.

Immunology today·2014
Same author

How does auranofin compare with methotrexate and cyclosporin as a corticosteroid-sparing agent in severe asthma?

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy·2007
Same author

Allergenicity of cry9c: an unresolved issue.

The Journal of allergy and clinical immunology·2001
Same author

Dopamine mediation of the feeding response to violations of spatial and temporal expectancies.

Behavioural brain research·2001
Same author

NaCl preference increases during pregnancy and lactation: assessment using brief access tests.

Pharmacology, biochemistry, and behavior·2001
Same author

NaCl detection thresholds: comparison of Fischer 344 and Wistar rats.

Chemical senses·2001
Same journal

PM<sub>2.5</sub> exposure impairs mitochondrial function and myocardial contractility in cardiac organoids via the Sirt3/Mdh2 pathway.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Evaluation of an in-vitro test protocol using a three-dimensional human buccal oral mucosal model to assess the oral medical devices.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Descriptive oxidative and lipid-related fluorescence observations associated with Esketamine treatment in a high-concentration NMDA-exposed HT-22/C8-D1A co-culture model.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Integration of label-free electrochemical sensing, differential privacy deep learning, and blockchain for secure cytotoxicity monitoring.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

Pulmonary permeability assessment using two human lung epithelial cell models in air-liquid interface cultures.

Toxicology in vitro : an international journal published in association with BIBRA·2026
Same journal

In vivo toxicity of some cyanide-containing compounds in zebrafish (Danio rerio) embryos.

Toxicology in vitro : an international journal published in association with BIBRA·2026
See all related articles

Related Experiment Video

Updated: Jun 10, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Respiratory allergy: Clinical aspects.

I L Bernstein1

  • 1Division of Immunology, Department of Medicine, University of Cincinnati Medical Center, 231 Bethesda Avenue, M.L. no. 563, Cincinnati, OH 45267, USA.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
|August 10, 2010
PubMed
Summary
This summary is machine-generated.

Chemicals can cause lung disease, particularly through workplace exposure and drug reactions. This review examines the immunotoxicological impact on various lung components, focusing on IgE-mediated hypersensitivity.

More Related Videos

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Related Experiment Videos

Last Updated: Jun 10, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
06:08

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

Published on: September 22, 2023

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Area of Science:

  • Pulmonary Medicine
  • Immunotoxicology
  • Environmental Health

Background:

  • Human pulmonary disease from chemical exposure varies by location and circumstance.
  • Epidemiological studies are the primary source of environmental hazard information.
  • Workplace exposure serves as a model for air pollution studies, and drug reactions cause pulmonary immunotoxicology.

Purpose of the Study:

  • To review the immunotoxicological impact of chemicals on the respiratory system.
  • To examine the roles of IgE, other antibodies, and complement in chemical-induced lung disease.
  • To identify specific chemicals and conditions affecting the airways and lung parenchyma.

Main Methods:

  • Literature review of immunotoxicological impacts of chemicals on lung components.
  • Analysis of epidemiological data and case studies.
  • Focus on IgE-mediated and cell-mediated immune responses.

Main Results:

  • Chemicals impact conducting airways, alveolar, interstitial, capillary compartments, pleura, and pulmonary vasculature.
  • IgE-mediated and cell-mediated responses are the major hypersensitivity types induced by chemicals.
  • Polyisocyanates, acid anhydrides, and platinum salts are linked to IgE sensitization and airway effects.
  • Hypersensitivity pneumonitis, drug-induced pneumonia, and berylliosis exemplify lung parenchymal conditions.

Conclusions:

  • Chemicals significantly impact lung health through various immunotoxicological mechanisms.
  • IgE-mediated responses are key in airway diseases caused by specific chemicals.
  • Understanding these pathways is crucial for managing and preventing chemical-induced lung conditions.