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Updated: Jun 10, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Cutaneous manifestations of complement deficiencies.

D Lipsker¹, G Hauptmann

¹Faculté de Médecine, Université de Strasbourg, Clinique Dermatologique, France. dan.lipsker@chru-strasbourg.fr

|August 10, 2010

Summary

This summary is machine-generated.

Complement deficiencies can cause hereditary angioedema and lupus erythematosus, affecting skin and leading to severe infections. Diagnosis involves assessing C1 esterase inhibitor and complement component levels.

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Last Updated: Jun 10, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

Immunology
Dermatology
Genetics

Background:

Complement system deficiencies are linked to various diseases.
Cutaneous manifestations are key indicators of these deficiencies.
Hereditary angioedema and lupus erythematosus are discussed in relation to complement defects.

Purpose of the Study:

To review cutaneous manifestations of complement deficiencies.
To detail hereditary angioedema and lupus erythematosus associated with complement system defects.
To explore the genetic background and clinical associations of complement component deficiencies.

Main Methods:

Literature review of complement system deficiencies.
Analysis of clinical presentations, including cutaneous signs.
Discussion of diagnostic approaches for hereditary angioedema and lupus erythematosus.

Main Results:

Hereditary angioedema results from C1 esterase inhibitor deficiency, presenting with swelling and gastrointestinal symptoms.
Complement deficiencies (C1q, C1r, C1s, C2, C4) are strongly associated with systemic lupus erythematosus.
Severe infections and photosensitivity suggest underlying complement deficiency in lupus patients.

Conclusions:

Complement deficiencies significantly impact skin health and immune function.
Understanding these associations aids in diagnosing and managing related diseases.
Genetic and clinical factors are crucial for comprehending complement-related disorders.