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Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
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A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

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Published on: November 9, 2016

Paediatric dosing errors before and after electronic prescribing.

Yogini Hariprasad Jani1, Nick Barber, Ian Chi Kei Wong

  • 1Centre for Paediatric Pharmacy Research, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. yogini.jani@pharmacy.ac.uk

Quality & Safety in Health Care
|August 10, 2010
PubMed
Summary
This summary is machine-generated.

Implementing electronic prescribing (EP) significantly reduced dosing errors in pediatric care. While the overall rate of errors decreased, further research is needed to fully understand the impact on error severity.

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Improving IV Insulin Administration in a Community Hospital
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Published on: June 11, 2012

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Last Updated: Jun 10, 2026

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Published on: June 11, 2012

Area of Science:

  • Pediatric pharmacology
  • Health informatics
  • Medication safety

Background:

  • Dose prescribing errors pose a significant risk in pediatric healthcare.
  • Electronic prescribing systems aim to mitigate medication errors.

Purpose of the Study:

  • To evaluate the impact of an electronic prescribing system on the incidence and severity of dose prescribing errors in a pediatric hospital.

Main Methods:

  • Prescription review was used to identify dose errors.
  • A validated scoring tool and expert judges assessed error severity.
  • Data was compared pre- and post-implementation of the electronic prescribing system.

Main Results:

  • The incidence of dose prescribing errors decreased from 2.2% to 1.2% after implementing electronic prescribing (p<0.001).
  • A statistically significant reduction was observed in errors with potentially minor (p=0.009) and moderate (p=0.019) outcomes.
  • While a trend towards reduced severe outcomes was noted, it did not reach statistical significance (p=0.11).

Conclusions:

  • Electronic prescribing shows promise in reducing dosing error rates in pediatric settings.
  • Larger studies are necessary to confirm the effect on error severity and generalizability across different healthcare environments.