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Related Concept Videos

Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Observational Studies01:11

Observational Studies

Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One example of...
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Case Studies01:22

Case Studies

There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.

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Related Experiment Video

Updated: Jun 10, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Na&#239;ve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Catatonic schizophrenia: a cohort prospective study.

Karine Kleinhaus1, Susan Harlap, Mary C Perrin

  • 1Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. kleink03@nyumc.org

Schizophrenia Bulletin
|August 10, 2010
PubMed
Summary

Catatonic schizophrenia may have distinct risk factors and is linked to higher suicide attempt rates compared to other schizophrenia subtypes. This suggests a potentially unique cause for catatonia in schizophrenia patients.

Related Experiment Videos

Last Updated: Jun 10, 2026

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Na&#239;ve Adolescents at High Risk for Psychosis
05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Area of Science:

  • Psychiatry
  • Schizophrenia Spectrum and Other Psychotic Disorders
  • Neuroscience

Background:

  • Historically, catatonia was classified as a schizophrenia subtype.
  • Recent research prompts a re-evaluation of catatonia's classification and nature.
  • This study investigates catatonic schizophrenia using novel prospective data.

Purpose of the Study:

  • To prospectively describe catatonia in schizophrenia.
  • To compare risk factors of catatonic schizophrenia with other schizophrenia subtypes.
  • To explore potential etiological differences in catatonic schizophrenia.

Main Methods:

  • Analysis of a large cohort (90,079 offspring) followed from birth to ages 29-41.
  • Utilized proportional hazards models to assess time to first psychiatric hospital admission.
  • Compared risk factors for catatonic vs. other schizophrenia.

Main Results:

  • Catatonic schizophrenia occurred in 7.6% of schizophrenia cases (43/568).
  • Unlike other schizophrenia (higher in males), catatonic schizophrenia affected sexes equally.
  • Advancing paternal age increased risk for other schizophrenia, but not catatonic schizophrenia.
  • Older maternal age showed a trend towards increased risk for catatonic schizophrenia.
  • Patients with catatonic schizophrenia had significantly higher rates of suicide attempts.

Conclusions:

  • Catatonic schizophrenia presents a distinct risk factor profile compared to other schizophrenia types.
  • The higher likelihood of suicide attempts in catatonic schizophrenia warrants attention.
  • Findings support the hypothesis of a potentially distinct etiology for catatonic schizophrenia.