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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Pedigree Analysis01:35

Pedigree Analysis

Overview
Probability Laws01:49

Probability Laws

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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
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Published on: June 21, 2018

Inheritance patterns, consanguinity & risk for asthma.

Bijanzadeh Mahdi1, P A Mahesh, R Savitha Mysore

  • 1Department of Studies in Zoology, University of Mysore, J.S.S. Medical College, J.S.S. Hospital, Mysore, India.

The Indian Journal of Medical Research
|August 10, 2010
PubMed
Summary
This summary is machine-generated.

A family history of asthma and consanguineous marriage significantly increase asthma risk in offspring. The study found a recessive inheritance pattern for asthma in the Indian population.

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Published on: August 7, 2017

Area of Science:

  • Genetics and Environmental Health
  • Respiratory Medicine
  • Epidemiology

Background:

  • Family history is a known risk factor for asthma, influenced by genetic and environmental interactions.
  • Limited data exists on asthma inheritance patterns within the Indian population.
  • Understanding inheritance is crucial for risk assessment and management.

Purpose of the Study:

  • To investigate asthma inheritance patterns in the Indian population.
  • To evaluate the impact of family history on asthma development.
  • To assess the role of consanguineous marriage in asthma inheritance.

Main Methods:

  • Study included 200 families: 100 with index asthmatic children/adults and 100 controls.
  • Detailed family history data was collected for all participants.
  • Pedigree analysis was performed to understand inheritance patterns.

Main Results:

  • Asthma was present in 44.5% of families with asthmatic individuals versus 5.3% in controls (P<0.001).
  • Consanguineous marriages were more frequent in asthmatic families (24.5%) compared to controls (12.3%) (P<0.001).
  • The most common inheritance pattern observed for asthma was recessive.

Conclusions:

  • Family history of asthma is a significant determinant of asthma risk in offspring.
  • Consanguineous marriage is also identified as an important factor contributing to asthma development.
  • These findings highlight the genetic and familial components of asthma in the studied population.