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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 10, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
12:19

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Chemoimmunotherapy.

Leisha A Emens1

  • 1Department of Oncology, The Johns Hopkins University, 1650 Orleans St, Room 409, Bunting Blaustein Cancer Research Building, Baltimore, MD 21231-1000, USA. emensle@jhmi.edu

Cancer Journal (Sudbury, Mass.)
|August 10, 2010
PubMed
Summary

Cancer chemotherapy can boost anti-tumor immunity by inducing cancer cell death and disrupting immune suppression. Strategic use of chemotherapy with immunotherapy may improve patient outcomes.

Area of Science:

  • Immunology
  • Oncology
  • Pharmacology

Background:

  • Chemotherapy traditionally viewed as immunosuppressive due to myelosuppression.
  • Emerging evidence suggests chemotherapy can activate innate and adaptive immunity.
  • Chemotherapy's immunomodulatory effects are dose- and timing-dependent, especially with immunotherapy.

Purpose of the Study:

  • To explore the dual role of chemotherapy in cancer treatment.
  • To elucidate the mechanisms by which chemotherapy impacts the immune system.
  • To inform the development of effective chemoimmunotherapy strategies.

Main Methods:

  • Review of existing literature on chemotherapy and immune interactions.
  • Analysis of preclinical and clinical data on chemoimmunotherapy.

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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

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Last Updated: Jun 10, 2026

Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
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Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

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  • Investigation of cellular and molecular pathways involved.

    • Main Results:

    • Chemotherapy induces immunologically active tumor cell death, enhancing antitumor responses.
    • Certain chemotherapy drugs can overcome immune suppression and tolerance.
    • Drug dose and administration timing are critical for immunomodulatory effects.

    Conclusions:

    • Chemotherapy possesses significant immunomodulatory properties beyond direct cytotoxicity.
    • Understanding these immune interactions is key to optimizing chemoimmunotherapy.
    • Strategic chemoimmunotherapy holds promise for improved tumor regression and long-term patient benefit.