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Updated: Jun 10, 2026

HLA-Ig Based Artificial Antigen Presenting Cells for Efficient ex vivo Expansion of Human CTL

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Published on: April 11, 2011

Adoptive therapy using antigen-specific T-cell clones.

¹Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Division of Oncology, Department of Medicine, University of Washington, Seattle, WA, USA. cyee@fhcrc.org

Cancer Journal (Sudbury, Mass.)

|August 10, 2010

Summary

This summary is machine-generated.

Antigen-specific T-cell therapy uses isolated T-cell clones for adoptive transfer. This approach allows rigorous evaluation of factors influencing effective T-cell responses in patients.

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Area of Science:

Immunology
Cell Therapy
Adoptive Immunotherapy

Background:

T-cell therapy involves isolating and expanding antigen-specific T cells ex vivo for adoptive transfer.
T-cell clones offer a uniform cell population, enabling rigorous evaluation of response parameters.
Understanding intrinsic T-cell factors and extrinsic influences is crucial for effective therapy.

Purpose of the Study:

To discuss advances in isolating and expanding antigen-specific T-cell clones for human adoptive therapy trials.
To provide a framework for the advantages and limitations of using adoptively transferred T-cell clones.
To dissect the requirements for effective T-cell therapy by analyzing T-cell clone applications.

Main Methods:

Isolation and expansion of antigen-specific T-cell clones.
Evaluation of intrinsic T-cell factors (specificity, phenotype, function).
Consideration of extrinsic factors (conditioning, cytokines, immunomodulatory reagents).

Main Results:

Advances in isolating and expanding T-cell clones for clinical applications.
A framework detailing the benefits and drawbacks of T-cell clone therapy.
Insights into dissecting therapeutic requirements through T-cell clone analysis.

Conclusions:

T-cell clones are valuable tools for dissecting the requirements of effective adoptive T-cell therapy.
The judicious application of T-cell clones aids in understanding therapy parameters.
Further research and clinical trials are supported by advances in T-cell clone technology.