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Related Experiment Video

Updated: Jun 10, 2026

Single-unit In vivo Recordings from the Optic Chiasm of Rat
11:00

Single-unit In vivo Recordings from the Optic Chiasm of Rat

Published on: April 2, 2010

Taming the ketamine tiger. 1965.

Edward F Domino1

  • 1Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109-5632, USA. efdabcde@umich.edu

Anesthesiology
|August 10, 2010
PubMed
Summary

CI-581, a phencyclidine derivative, shows promise as an effective analgesic and anesthetic, offering rapid onset and short duration. Further clinical trials are recommended for this dissociative anesthetic.

Area of Science:

  • Pharmacology
  • Anesthesiology
  • Medicinal Chemistry

Background:

  • Investigated the pharmacologic actions of CI-581, a novel phencyclidine derivative.
  • Evaluated efficacy and safety in 20 male volunteers from a prison population.

Discussion:

  • CI-581 demonstrated effective analgesia and anesthesia at 1.0-2.0 mg/kg IV, with rapid onset (within 1 min) and short duration (5-10 min).
  • Undesirable effects included transient hypertension, tachycardia, and psychic changes.
  • No tachyphylaxis or significant liver/kidney toxicity observed.

Key Insights:

  • CI-581 acts as a potent analgesic and anesthetic with a short duration of action.
  • The drug induces a unique mental state, proposed to be termed a "dissociative anesthetic."
  • Recovery was rapid, though electroencephalographic normalization took 1-2 hours.

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Last Updated: Jun 10, 2026

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Outlook:

  • CI-581 warrants further pharmacologic and clinical investigation.
  • Potential for modifying adverse effects with preanesthetic medication requires study.
  • The classification as a "dissociative anesthetic" merits consideration for future research.