Related Experiment Video
Updated: Jun 10, 2026

Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
Published on: March 19, 2020
Synthesis and characterization of enantiopure copper(II) complexes using chiral bidentate ligands
Kil Sik Min1, A Hyun Park, Jong Won Shin
1Department of Chemistry Graduate School, Kyungpook National University, Daegu, 702-701, South Korea. minks@knu.ac.kr
Abstract:
Chiral copper(ii) complexes of the types [Cu(II)(R/S-ppme)(3)](ClO(4))(2) and [Cu(II)(R/S-ppme)(2)(SO(4))] have been synthesized by reactions of Cu(ClO(4))(2).6H(2)O and CuSO(4).5H(2)O with R/S-ppme in methanol under aerobic conditions (R/S-ppme = (R/S)-(+/-)-1-phenyl-N-(pyridine-2-ylmethylene)ethanamine). All complexes were isolated and characterized by X-ray crystallography and circular dichroism (CD): (Lambda)-[Cu(II)(R-ppme)(3)](ClO(4))(2) (1), (Delta)-[Cu(S-ppme)(3)](ClO(4))(2).H(2)O (2), (Delta)-[Cu(II)(R-ppme)(2)(SO(4))].4CH(3)OH (3), and (Lambda)-[Cu(II)(S-ppme)(2)(SO(4))].4CH(3)OH (4). 1 and 2 with ClO(4)(-) anions are formed as tris(R/S-ppme) copper(ii) complexes, while 3 and 4 with SO(4)(2-) are formed as bis(R/S-ppme) copper(ii) complexes. The structures of 1 with R-ppmes and 4 with S-ppmes show the same absolute configurations (Lambda). In contrast, 2 with S-ppmes and 3 with R-ppmes exhibit Delta configurations. In the electron paramagnetic resonance (EPR) spectra of 1 and 3, both compounds demonstrate z-axis elongated structures. The CD spectra of 1 and 2 show Cotton effects in an enantiomeric pattern; those of 3 and 4 also display the same effects.
Related Concept Videos
Complexation Equilibria: The Chelate Effect
Stereoisomerism
Isomers are different chemical species that have the same chemical formula.
Transition metal complexes often exist as geometric isomers, in which the same atoms are connected through the same types of bonds but with differences in their orientation in space. Coordination complexes with two different ligands in the cis and trans positions from a ligand of interest form isomers. For example, the octahedral [Co(NH3)4Cl2]+ ion has two isomers (Figure 1) In the cis...
Prochirality
Metal-Ligand Bonds
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
Extraction: Advanced Methods
Stereoisomerism of Cyclic Compounds

