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Sleep apnea is common in patients with coronary artery disease

Christian Prinz1, Thomas Bitter, Cornelia Piper

  • 1Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany, akleemeyer@hdz-nrw.de.

Wiener Medizinische Wochenschrift (1946)
|August 10, 2010
PubMed

Insights

Sleep-disordered breathing (SDB) is common in coronary artery disease (CAD) patients and linked to higher inflammation markers. This suggests SDB may worsen CAD progression or trigger acute cardiac events.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Inflammation Research

Background:

  • Sleep-disordered breathing (SDB) is a known factor impacting cardiac disease prognosis.
  • Coronary artery disease (CAD) patients often have undiagnosed sleep issues.
  • Chronic inflammation plays a role in the development and progression of CAD.

Purpose of the Study:

  • To investigate the prevalence of SDB in patients with established CAD and preserved left ventricular function.
  • To explore the association between SDB, systemic inflammation markers (hs-CRP, fibrinogen), and CAD.
  • To determine if SDB severity correlates with inflammatory markers in this patient group.

Main Methods:

  • Cardiorespiratory polygraphy was used to diagnose SDB in 257 CAD patients.
  • High-sensitivity C-reactive protein (hs-CRP) and fibrinogen levels were measured in 251 patients.
  • Patients were categorized based on SDB presence, type (central/obstructive), and hs-CRP levels.

Main Results:

  • SDB was prevalent in 188 (73%) of the CAD patients studied.
  • Patients with SDB exhibited significantly higher fibrinogen levels compared to those without SDB (p=0.01).
  • Higher hs-CRP levels (>0.5 mg/dl) were associated with significantly more severe SDB (p=0.01).

Conclusions:

  • SDB is highly prevalent in patients with coronary artery disease.
  • SDB in CAD patients is associated with elevated markers of chronic inflammation.
  • These findings suggest a potential link between SDB, inflammation, and CAD progression or acute coronary events.

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